Motif ID: FOX{C1,C2}.p2

Z-value: 0.503


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC1chr6_+_15565430.495.5e-02Click!
FOXC2chr16_+_851583570.341.9e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_158008763 1.083 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_-_155818728 1.023 NM_015718
NOX3
NADPH oxidase 3
chr2_+_189547323 0.960 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_+_189547358 0.877 COL3A1
collagen, type III, alpha 1
chr2_+_73973640 0.787 ACTG2
actin, gamma 2, smooth muscle, enteric
chr20_-_60435983 0.776 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr2_-_207291364 0.750 NM_001093730
DYTN
dystrotelin
chr2_+_189547377 0.748 COL3A1
collagen, type III, alpha 1
chr2_+_73973600 0.669 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr14_+_28306633 0.571 FOXG1
forkhead box G1
chr10_-_13316333 0.539 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr9_-_74735669 0.539 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_+_71054492 0.512 NM_214711
C4orf40
chromosome 4 open reading frame 40
chr7_-_98643024 0.491 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr20_-_43609409 0.488 NM_001198986
NM_020398
SPINLW1-WFDC6
SPINLW1
SPINLW1-WFDC6 readthrough
serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
chr11_-_67163600 0.454 NM_005995
TBX10
T-box 10
chr11_+_56224436 0.429 NM_001005213
NM_001013358
OR9G1
OR9G9
olfactory receptor, family 9, subfamily G, member 1
olfactory receptor, family 9, subfamily G, member 9
chr17_+_7563763 0.419 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr3_-_115826481 0.405 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr20_+_9146036 0.405 NM_182797
PLCB4
phospholipase C, beta 4
chr16_-_21130368 0.400 NM_003460
ZP2
zona pellucida glycoprotein 2 (sperm receptor)
chr14_-_93988838 0.392 NM_001080451
SERPINA11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
chr22_-_28992787 0.392 NM_020530
OSM
oncostatin M
chr9_+_139265533 0.392 NM_001004353
C9orf173
chromosome 9 open reading frame 173
chr5_+_140154627 0.391 NM_018905
NM_031495
PCDHA2

protocadherin alpha 2

chr5_+_35892747 0.385 NM_002185
IL7R
interleukin 7 receptor
chr9_+_115958051 0.385 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr22_+_29333069 0.380 NM_000355
NM_001184726
TCN2

transcobalamin II

chr8_+_55691179 0.360 NM_006269
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr11_-_57728228 0.350 NM_001004459
OR1S2
olfactory receptor, family 1, subfamily S, member 2
chr1_+_179148935 0.347 NM_020950
KIAA1614
KIAA1614
chr2_+_121271336 0.344 NM_005270
GLI2
GLI family zinc finger 2
chr11_+_117680504 0.332 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr12_+_25096755 0.329 LRMP
lymphoid-restricted membrane protein
chr17_-_39191658 0.329 NM_025237
SOST
sclerostin
chr14_+_94117483 0.325 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr9_-_35860316 0.325 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr4_+_71713324 0.318 NM_031889
ENAM
enamelin
chr2_+_48649662 0.308 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr19_-_14853166 0.307 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr2_+_158666627 0.305 NM_173355
UPP2
uridine phosphorylase 2
chr1_-_24112345 0.304 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr11_+_110890719 0.303 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr19_+_15058790 0.302 NM_001004713
OR1I1
olfactory receptor, family 1, subfamily I, member 1
chr2_-_216008689 0.299 FN1
fibronectin 1
chr20_-_43601542 0.296 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr4_-_47831002 0.292 NM_003328
TXK
TXK tyrosine kinase
chr11_-_116199145 0.290 NM_000482
APOA4
apolipoprotein A-IV
chr6_+_72982865 0.289 NM_001168409
RIMS1
regulating synaptic membrane exocytosis 1
chr12_+_50592379 0.289 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr10_-_17211795 0.286 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr5_+_176806401 0.283 NM_001174101
NM_030567
PRR7

proline rich 7 (synaptic)

chr1_-_149385556 0.277 NM_001178061
NM_001178062
NM_030913
SEMA6C


sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C


chr20_+_9442995 0.271 C20orf103
chromosome 20 open reading frame 103
chr1_-_155788775 0.268 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr5_+_140160966 0.268 NM_018906
NM_031497
PCDHA3

protocadherin alpha 3

chr14_+_99309688 0.263 EML1
echinoderm microtubule associated protein like 1
chrX_+_138440560 0.263 NM_000133
F9
coagulation factor IX
chr12_+_53901075 0.260 NM_001005280
OR10A7
olfactory receptor, family 10, subfamily A, member 7
chr6_-_169392771 0.259


chr9_-_106329310 0.258 NM_001001919
OR13C4
olfactory receptor, family 13, subfamily C, member 4
chr5_+_150000394 0.256 NM_001109974
NM_007286
SYNPO

synaptopodin

chrX_-_108611940 0.255 NM_001522
GUCY2F
guanylate cyclase 2F, retinal
chr7_+_5609416 0.254 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr7_-_50596238 0.252 NM_000790
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr4_-_100359353 0.251 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr5_+_357290 0.251 NM_020731
AHRR
aryl-hydrocarbon receptor repressor
chr1_-_36721010 0.249 CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr4_+_17125885 0.243 NM_001079827
CLRN2
clarin 2
chr7_-_50600536 0.243 NM_001082971
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr11_+_48194937 0.242 NM_001005470
OR4B1
olfactory receptor, family 4, subfamily B, member 1
chr5_+_127012611 0.242 NM_001048252
CTXN3
cortexin 3
chr11_+_120478584 0.241 NM_005422
TECTA
tectorin alpha
chr3_+_153014550 0.240 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr4_-_38534802 0.239 NM_006068
TLR6
toll-like receptor 6
chr5_+_72504778 0.239 NM_153217
TMEM174
transmembrane protein 174
chr10_-_60792225 0.236 NM_001001971
NM_001166698
NM_198215
FAM13C


family with sequence similarity 13, member C


chr21_-_42608774 0.235 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr5_+_140181405 0.235 NM_018908
NM_031501
PCDHA5

protocadherin alpha 5

chr15_+_84486245 0.234 NM_152336
AGBL1
ATP/GTP binding protein-like 1
chr19_+_10900502 0.233 C19orf52
chromosome 19 open reading frame 52
chr16_+_85158357 0.231 NM_005251
FOXC2
forkhead box C2 (MFH-1, mesenchyme forkhead 1)
chr5_+_140146059 0.231 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr15_+_100175888 0.230 NM_001001674
OR4F15
olfactory receptor, family 4, subfamily F, member 15
chr1_-_53972464 0.229 NM_147193
GLIS1
GLIS family zinc finger 1
chr6_+_47732181 0.228 NM_153839
GPR111
G protein-coupled receptor 111
chr5_+_131424245 0.222 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr1_-_56750235 0.215 PPAP2B
phosphatidic acid phosphatase type 2B
chr7_+_73826244 0.215 NM_000265
NCF1
NCF1B
NCF1C
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
neutrophil cytosolic factor 1C pseudogene
chr4_+_71298187 0.214 NM_021225
PROL1
proline rich, lacrimal 1
chr17_+_7402315 0.200 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr19_-_59309719 0.198 TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr2_-_49235059 0.197 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr19_+_47509274 0.194 NM_173633
TMEM145
transmembrane protein 145
chr17_+_3065661 0.194 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr4_-_68678181 0.194 NM_207407
TMPRSS11F
transmembrane protease, serine 11F
chr21_-_42689192 0.192 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr1_+_150958621 0.188 NM_001024679
C1orf68
chromosome 1 open reading frame 68
chr1_+_64442077 0.186 NM_152489
UBE2U
ubiquitin-conjugating enzyme E2U (putative)
chr20_+_56722188 0.185


chr5_-_156525756 0.183 NM_130899
FAM71B
family with sequence similarity 71, member B
chr19_+_10900419 0.183 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr21_+_42697058 0.182 NM_001001895
NM_018961
UBASH3A

ubiquitin associated and SH3 domain containing A

chr1_-_157772420 0.181 NM_001004469
OR10J5
olfactory receptor, family 10, subfamily J, member 5
chr18_+_41558141 0.178 SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr1_+_158352143 0.177 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_-_25164061 0.177 NM_001031680
RUNX3
runt-related transcription factor 3
chr4_+_186587537 0.176 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr1_+_103961476 0.176 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr19_+_43502360 0.174 KCNK6
potassium channel, subfamily K, member 6
chr8_-_124818754 0.171 NM_001003954
NM_004306
ANXA13

annexin A13

chr11_+_60626505 0.171 NM_014207
CD5
CD5 molecule
chr18_-_54447168 0.170 NM_052947
ALPK2
alpha-kinase 2
chrX_-_77801480 0.170 NM_152694
ZCCHC5
zinc finger, CCHC domain containing 5
chr17_-_16816113 0.169 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr3_-_192531018 0.169 NM_198152
UTS2D
urotensin 2 domain containing
chr4_-_3503951 0.168 NM_002337
LRPAP1
low density lipoprotein receptor-related protein associated protein 1
chr6_-_29163027 0.167 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr11_-_5946299 0.163 NM_001146033
OR56A5
olfactory receptor, family 56, subfamily A, member 5
chr17_+_41278035 0.163 NM_175882
IMP5
intramembrane protease 5
chr5_+_156752739 0.162 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr6_-_117256890 0.160 NM_148963
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr14_+_73884947 0.159 VRTN
vertebrae development homolog (pig)
chr14_-_44046202 0.159 NM_032135
FSCB
fibrous sheath CABYR binding protein
chr4_+_166519392 0.159 NM_001873
CPE
carboxypeptidase E
chr6_+_123142559 0.158 FABP7
fatty acid binding protein 7, brain
chr20_+_42417752 0.155 NM_001030003
NM_001030004
NM_175914
HNF4A


hepatocyte nuclear factor 4, alpha


chr11_+_66547391 0.155 NM_177963
SYT12
synaptotagmin XII
chr3_+_115099007 0.155 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr14_+_94117511 0.155 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_+_46176105 0.154 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr7_+_141265085 0.154 NM_001001656
OR9A4
olfactory receptor, family 9, subfamily A, member 4
chr11_-_13474101 0.154 NM_000315
PTH
parathyroid hormone
chr3_+_110024234 0.154 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr4_-_3503881 0.154 LRPAP1
low density lipoprotein receptor-related protein associated protein 1
chr16_-_31068329 0.154 PRSS36
protease, serine, 36
chr5_-_160211623 0.154 NM_025153
ATP10B
ATPase, class V, type 10B
chr5_+_140454382 0.152 NM_018936
PCDHB2
protocadherin beta 2
chr15_+_38843535 0.151 NM_005258
GCHFR
GTP cyclohydrolase I feedback regulator
chr1_+_151081953 0.149 NM_001128600
LCE6A
late cornified envelope 6A
chr5_+_54355840 0.146 NM_002104
GZMK
granzyme K (granzyme 3; tryptase II)
chr12_-_49897743 0.145 POU6F1
POU class 6 homeobox 1
chr16_-_70763524 0.143 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr10_-_82039158 0.143 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr17_-_77233966 0.143 NM_002602
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr7_-_56128098 0.141 NM_006213
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr21_-_42608531 0.141 TFF3
trefoil factor 3 (intestinal)
chr4_-_118226119 0.139 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr14_+_87541220 0.139 NM_003608
GPR65
G protein-coupled receptor 65
chr5_+_140777454 0.139 NM_018927
NM_032101
PCDHGB7

protocadherin gamma subfamily B, 7

chr12_+_70618892 0.138 NM_173353
TPH2
tryptophan hydroxylase 2
chr17_-_64649608 0.137 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr11_-_6418705 0.136 NM_000613
HPX
hemopexin
chr12_+_54231249 0.132 NM_001005494
OR6C4
olfactory receptor, family 6, subfamily C, member 4
chr5_-_88004891 0.132 LOC645323
hypothetical LOC645323
chr6_+_31016755 0.131 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr10_-_99780336 0.131 CRTAC1
cartilage acidic protein 1
chr12_+_8216416 0.130 NM_001004328
ZNF705A
zinc finger protein 705A
chr14_+_23849196 0.129 NM_001164692
NM_019839
LTB4R2

leukotriene B4 receptor 2

chr11_+_113672407 0.129 NNMT
nicotinamide N-methyltransferase
chr10_+_7785347 0.126 ITIH2
inter-alpha (globulin) inhibitor H2
chr8_+_70567634 0.125 SULF1
sulfatase 1
chr8_-_21701616 0.122 GFRA2
GDNF family receptor alpha 2
chr10_+_96688399 0.122 NM_000771
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr17_+_8154864 0.122 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr3_-_166397142 0.122 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr14_+_73884918 0.119 NM_018228
VRTN
vertebrae development homolog (pig)
chr3_-_42892195 0.119 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr4_+_88973144 0.119 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr10_+_7785360 0.118 ITIH2
inter-alpha (globulin) inhibitor H2
chr21_-_37366684 0.118 NM_153681
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr8_-_95298706 0.117 NM_001144663
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr4_+_120276386 0.117 NM_016599
MYOZ2
myozenin 2
chr5_-_22248630 0.117 CDH12
cadherin 12, type 2 (N-cadherin 2)
chr19_+_14913298 0.117 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr17_+_37967617 0.117 NM_001042529
NM_001042530
NM_001042531
NM_001042532
NM_025233
COASY




CoA synthase




chr2_+_137464931 0.114 NM_001080427
THSD7B
thrombospondin, type I, domain containing 7B
chr17_+_76988134 0.114 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr1_+_85300580 0.113 NM_145172
WDR63
WD repeat domain 63
chr8_+_54955962 0.113 NM_003702
RGS20
regulator of G-protein signaling 20
chr17_-_36347197 0.113 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr7_-_55897938 0.112 NM_207366
SEPT14
septin 14
chr11_+_113672378 0.111 NNMT
nicotinamide N-methyltransferase
chr5_+_79366746 0.109 NM_003248
THBS4
thrombospondin 4
chr3_-_117647053 0.109 NM_002338
LSAMP
limbic system-associated membrane protein
chr10_+_7785290 0.109 ITIH2
inter-alpha (globulin) inhibitor H2
chr8_-_23619866 0.108 NM_001136271
NKX2-6
NK2 transcription factor related, locus 6 (Drosophila)
chr12_+_6424293 0.108 NM_001242
CD27
CD27 molecule
chr1_-_68688219 0.107 NM_000329
RPE65
retinal pigment epithelium-specific protein 65kDa
chr18_+_50409387 0.107 NM_173629
C18orf26
chromosome 18 open reading frame 26
chr8_-_27171814 0.106 NM_030795
STMN4
stathmin-like 4
chr1_+_245818284 0.106 NM_001001915
OR2G2
olfactory receptor, family 2, subfamily G, member 2
chr11_+_93940121 0.106 NM_152431
PIWIL4
piwi-like 4 (Drosophila)
chr2_+_69055208 0.105 NM_019617
GKN1
gastrokine 1
chr14_+_19414230 0.104 NM_001005501
OR4K2
olfactory receptor, family 4, subfamily K, member 2
chr4_+_74491272 0.103 ALB
albumin
chr12_+_25096472 0.102 NM_006152
LRMP
lymphoid-restricted membrane protein
chr6_-_41230003 0.101 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr12_+_115455579 0.100 NCRNA00173
non-protein coding RNA 173
chr19_+_6981593 0.100 NM_001136507
MBD3L5
methyl-CpG-binding domain protein 3-like 5-like

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.77 1.72e-09 GO:0007608 sensory perception of smell
3.37 5.33e-08 GO:0007606 sensory perception of chemical stimulus
2.49 4.38e-06 GO:0007600 sensory perception
1.86 1.47e-04 GO:0003008 system process
1.95 3.09e-04 GO:0050877 neurological system process
1.39 6.53e-04 GO:0032501 multicellular organismal process
2.98 8.56e-03 GO:0016337 cell-cell adhesion
2.39 2.24e-02 GO:0009967 positive regulation of signal transduction
2.35 2.31e-02 GO:0023056 positive regulation of signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.68 1.03e-11 GO:0071944 cell periphery
1.67 2.67e-11 GO:0005886 plasma membrane
1.82 1.34e-06 GO:0005576 extracellular region
1.42 1.35e-06 GO:0031224 intrinsic to membrane
1.37 3.34e-06 GO:0044425 membrane part
1.41 4.60e-06 GO:0016021 integral to membrane
1.30 1.13e-05 GO:0016020 membrane
2.93 8.89e-05 GO:0031012 extracellular matrix
1.97 5.94e-04 GO:0044421 extracellular region part
2.85 1.53e-03 GO:0005578 proteinaceous extracellular matrix
1.59 1.73e-03 GO:0044459 plasma membrane part
1.76 8.06e-03 GO:0005887 integral to plasma membrane
1.73 1.33e-02 GO:0031226 intrinsic to plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.31 8.25e-13 GO:0004872 receptor activity
2.54 2.75e-12 GO:0004888 transmembrane receptor activity
2.10 8.62e-12 GO:0004871 signal transducer activity
2.10 8.62e-12 GO:0060089 molecular transducer activity
4.05 1.80e-11 GO:0004984 olfactory receptor activity
2.74 1.64e-09 GO:0004930 G-protein coupled receptor activity
2.11 9.83e-03 GO:0005509 calcium ion binding
16.78 1.84e-02 GO:0016175 superoxide-generating NADPH oxidase activity
6.61 2.56e-02 GO:0003823 antigen binding